摘要
应用免疫酶标玻片法检测了宫颈癌高发区101例宫颈非典型增生、66例宫颈原位癌、61例宫颈浸润癌病人以及193例健康妇女血清中的 HSV-1和 HSV-2抗体。在年龄、初婚年龄、初产年龄、足月产次、结婚次数等与性行为和生育有关的因素方面将病人与健康妇女配对后,发现宫颈非典型增生、宫颈原位癌、宫颈浸润癌病人的 HSV-2抗体阳性率和几何平均滴度高于相应对照妇女。本研究提示 HSV-2感染与宫颈癌的发生有关联.
An immunoenzymatic slide method was used to detect antibodies to herpes simplex virus type 1 and 2 in sera from 101 patients with cervical dysplasia,66 patients with cervical cancer and 193 con- trol women.After the control women were matched with cases according to attributes presumed related to the incidence of cervival cancer,such as age,age at first marriage,age at first birth,number of live births and number of marriages,the frequency and geometric mean tiler of antibody to HSV-2 among patients with dysplasia,patients with carcinoma in situ and patients with invasive carcinoma were sig- nificantly higher than that of the control.These findings suggest that the association between HSV-2 and cervical cancer is not simply one of covariability of sexual promiscuity and possibly represents one of causation.
关键词
子宫颈瘤
人疱疹病毒
抗体
病因
MeSH cervix neoplasms/ET
herpesvirus homuns/PY
antibodies/AN
epidemiologic methods
