纤维蛋白原与冠心病的相关性探讨

Correlation Between Fibrinogen and Coronary Heart Disease

目的:了解血浆纤维蛋白原与冠心病的相关性。方法:选择276例冠心病患者(冠心病组),其中急性心肌梗死80例,不稳定型心绞痛104例,稳定型心绞痛92例;170例健康体检者作对照组,分别采集空腹静脉血,测定血浆纤维蛋白原、血脂、血糖、血肌酐,并分析血浆纤维蛋白原与冠心病的相关性。结果:冠心病组与对照组血浆纤维蛋白原比较差异具有显著的统计学意义(P<0.05),而冠心病组中急性心肌梗死、不稳定型心绞痛、稳定型心绞痛患者间两两比较,差异无显著统计学意义(P>0.05),血浆纤维蛋白原与血脂间相关分析表明两者无相关性(P>0.05)。结论:血浆纤维蛋白原是冠心病的独立危险因素及预测因素。

Objective：To explore the level of fibrinogen （Fib） and the relationship between Fib and coronary heart disease （CHD）. Methods ：The level of Fib and serum lipids were measured in 276 patient with various CHD（ among whom 80 were AMI, 104 were unstable angina and 92 were stable angina）and 170 healthy controls. Both groups had intraveneous blood tests to evaluate Fib,blood fat, blood sugar and serum creatinine and to analyze the correlation between Fib and CHD. Results.The level of Fib in CHD were different with that of the healthy group （P 〈 0.05） . The levels of Fib in CHD were not significantly different between various CHD groups （P 〉0.05）. There was no correlation between Fib and Serum Lipids （P 〉 0.05 ）. Conclusion：Fib may be the independent risk factors of CHD.