门诊流动人口性病就诊者支原体检测及耐药情况分析

Infection status and antimicrobial resistance of mycoplasma in STD patients in fluid population

目的了解性病门诊外来流动人口患者支原体感染及耐药情况。方法对1200例性病门诊患者进行了支原体培养鉴定及抗菌药物敏感性试验。结果支原体Uu和(或)Mh阳性总检出率为49.3%(592/1200),其中单纯Uu阳性率82.6%(489/592),单纯Mh阳性5.9%(35/592),Uu+Mh混合感染11.5%(68/592)。男性感染率为34.5%(204/592),女性感染率为65.5%(388/592),女性支原体感染率高于男性(P<0.05)。耐药性最高的分别为环丙沙星(72.3%)、氧氟沙星(66.0%)、壮观霉素(31.6%),敏感性最高的分别为强力霉素(89.2%)、交沙霉素(83.8%)、罗红霉素(81.3%)、美满霉素(76.4%)和克拉霉素(76.4%)。结论支原体感染依然是外来流动人口非淋菌性尿道(宫颈)炎主要的病因,监测支原体的耐药性对指导临床合理使用抗生素具有重要意义。

Objective To realize infection status and antibiotic resistance of mycoplasma from patients in fluid population in order to apply correct treatment in STD. Methods 1200 patients were cho- sen to test ureaplasma urealyticum（UU）, mycoplasma hominis （MH）and Uu＋Mh at STD clinic,at the same time the drug sensitivity was analyzed. Results The total infection rates were 49.3%（592/1200）. The infection rates of UU, MH and UU ＋MH were 82.6%（489/592）, 5.9%（35/592）, and 11.5% （68/592）respectively. The infection rate in female was 65.5%, higher than that （34.5%）in male （P 0.05）. 72.3% of Uu and/or Mh were resistant to ciprofloxacin. 66.0% of them were resistant to of loxacin. 31.6 % of them were resistant to actinospectacin. Listing the drug sensitivity from high to low was deoxycycline（89.2%）, josamycin（83. 8%）, roxithromycin（81.3%）, minocycline（76.4%）, Clarithromycin（76. 4%）. Conclusions The mycoplasma infection is still the main causative agent of nongonococcal urethritis （cervicitis）. The Surveillance study on mycoplasma resistance is very important.