肝病患者血浆高密度脂蛋白亚组份的变化

Variability of High-Density Lipoprotein Subfractions in Plasma of Patients with Live Disease

检查急性黄疸型病毒性肝炎、慢性活动性肝炎、肝硬化及肝癌患者血浆 HDL,其所含 Ch 和 Apo-AI 均较正常人低(P<0.01),急性黄疸型病毒性肝炎与慢性活动性肝炎患者 HDL_2及HDL_3中的 Ch、Apo-AI 皆明显降低,但前者 HDL_3-C/HDL_2-C 增高,HDL_2中 Ch/Apo-AI 降低,后者则无上述差异;肝硬化患者仅 HDL_3降低,其中 Ch 为0.41mmol/L,Apo-AI 为4.88mg/L;肝癌患者可见HDL_2降低,其中 Ch 为0.19mmol/L,Apo-AI 为1.17mg/L,HDL_3及 Apo-AI 降低,表明不同肝病具有不同的特征性改变。

HDL in plasma in 22 patients with acute icteric virulent hepatitis(AIVH),10 with chronic active hepatitis(CAH),7 with liver cirrhosis(LC)and 11 with hepatic cellular carcinoma(HCC)were deter- mined.HDL cholesterol(HDL-C)and HDL apoproteinA I(HDL-AI)in all cases were decreased in comparison with the healthy subjects.The Ch.ApoAI in HDL_2 and HDL_3 of patients with AIVH and CAH were decreased significantly.The HDL_3-C/HDL_2-C was increased and ch/ApoAI in HDL_2 was decreased in AIVH.However there was no difference in CAH.Ch and ApoAI in HDL_3 were only de- creased in patients with LC.Contrary to the results of LC,the Ch and ApoAI in HDL_2 were decreased and there was only decreased ApoAI in HDL_3 in HCC. In conclusion there is characteristic varability of HDL subfractions in different liver disease.It is uncertain whether it will provide the diagnosis basis.