摘要
心肌反复短暂缺血或戊脉安均可抑制急性心肌梗塞(AMI)再灌注后血小板聚集功能的增强及血浆 TXB_2水平的增高反应,并缩小其梗塞灶。而反复短暂心肌缺血联合应用戊脉安既不能进一步降低 AMI 再灌注后的血小板聚集功能及血浆 TXB_2水平,也不能进一步缩小其梗塞灶。
The effects of repetitive brief episodes of ischemia and its combination with verapamil on acute mycardial infarct-reperfusion(AMI-R)were studied in open-chest rabbits. These data indicate that preconditioning repetitive brief ischemia or verapamil can limit the infarct size and inhibit the increas- ing reaction of platelet aggregation and plasma TXB_2 level after AMI-R. But verapamil could not fur- ther decrease the infarct size or the platelet aggregation and plasma TXB_2 level after AMI-R precondi- tioned with repetitive brief episedes of ischemia.
关键词
心肌梗塞
心肌缺血
戊脉安
药效
myocardial infarction/PA
coronary disease/PA
verapamil/PD
platelet aggregation/DE
rabbits
animal,laboratory
