培哚普利和川芎嗪治疗慢性肺源性心脏病加重期36例疗效观察

Effect observation of Perindopril and Ligustrazine on 36 Chronic cor pulmonale anabasis patients

目的探讨培哚普利和川芎嗪治疗慢性肺源性心脏病急性加重期的临床疗效。方法36例患者在常规治疗基础上加用培哚普利和川芎嗪作为治疗组,36例仅用常规治疗做对照组。观察用药前后的症状、体征和呼吸、心率、氧饱和度(SaO2)变化情况,检查血、尿常规,肝、肾功能,血清钾、钠和心电图。结果治疗组36例患者总有效率为91.7%,对照组36例总有效率为72.2%。两组相比差异具有统计学意义(P<0.05)。结论培哚普利和川芎嗪改善肺源性心脏病心功能疗效确切。

Objective Investigating clinical curative effect of Perindopril and Lignstrazine on Chronic cor pulmonale. Methods 36 patients of therapeutic group treated with Perindopril and Lignstrazine as well as conventional therapy, and using other 36 patients only treated with conventional therapy as control group. Observing the changes of their symptom, physical sign, respiration, heart rate and oxygen percent saturation before medication and after it , in addition, examining their blood, urine, liver function, renal function, serum potassium, serum natrium and electrocardiogram. Results The total effective rate of therapeutic group was 91.7%, and it of control group was 72.2%. The difference of these two groups has statistical significance（ P 〈 0.05 ）. Conclusion The curative effect of Perindopril and Lignstrazine on improving cardiorespiratory function of Chronic cor pulmonale patients is very precise.