高血压患者血浆Apelin与左心室肥厚及颈动脉粥样硬化的关系

Correlation of Plasma Apelin to Left Ventricular Hypertrophy and Carotid Atherosclerosis in Patients with Essential Hypertension

目的观察高血压患者血浆Apelin水平变化,探讨其与左心室肥厚和颈动脉粥样硬化的关系。方法选择原发性高血压患者125例,根据超声结果分为心肌肥厚组、内膜中膜增厚组、颈动脉斑块组和单纯高血压组,另选31例经体检筛选的健康者为对照组。采用酶联免疫分析法测定血浆Apelin含量。结果心肌肥厚组血浆Ape-lin含量(616±112ng/L)明显低于对照组(757±176ng/L)和单纯高血压组(715±170ng/L,P<0.001或0.05);并且血浆Apelin含量在内膜中膜增厚组(613±133ng/L)和颈动脉斑块组(592±146ng/L)均显著低于单纯高血压组和对照组(P<0.001或0.05)。相关分析表明,血浆Apelin水平与左心室质量指数、内膜中膜厚度和斑块指数均呈明显负相关(r分别为-0.253、-0.255和-0.246,P均<0.05)。结论血浆Apelin水平可能参与高血压心室重构和动脉硬化的发生与发展过程。

Aim To investigate the relationship of plasma Apelin with left ventrieular hypertrophy and carotid artery disease, and to observe the change of plasma Apelin levels in patients with hypertension. Methods 125 essential hypertensive patients and 31 healthy controls were selected. All patients with hypertension were divided into left ventrieular hypertrophy group, intima-media thickeness group , carotid artery plaque group and simple hypertension group according to the measuring resuits by ultrasonography. The levels of plasma Apelin were determined by enzyme immunoassay. Results The plasma Apelin levels were significantly lower in left ventrieular hypertrophy group （616± 112 ng/L） than in control group （757 ± 176 ng/L） and simple hypertension group （715 ± 170 ng/L, P 〈 0.01 or 0.05）. The plasma Apelin levels were decreased in intima-media thickness group （613± 133 ng/L） and carotid artery plaque group （592± 146 ng/L） compared with control group and simple hypertension group （P〈0.001 or0.05）. There were negative correlation between left ventricular mass index , intirna-mediathiekhess, earolid artery plaque index and plasma Apelin （respectively r = -0.253 , r = -0.255 and r = -0.246,P 〈0.05）. Conclusion Apelin may participate in the pathophysiological process of myocardial hypertrophy and atherescleresis.