成人标准肝体积预测公式的初步构建

Establishment of formula predicting adult standard liver volume for liver transplantation

目的建立一个预测中国成人标准肝体积的公式。方法收集2005年3月至2007年12月90例活体肝移植供者的临床资料，包括供者的性别（G）、年龄（Y）、身高（BH）、体重（BW）和术前CT扫描测量的全肝体积（TLV）。分析TLV与上述其他指标的相关性，通过多重逐步线性回归得出预测标准肝体积的回归方程。并比较该公式和文献报道的公式预测的标准肝体积（ESLV）之间是否有差异。结果90例供者的平均体重为（62．4±8．7）kg，平均TLV为（1319．1±167．0）ml，二者成正相关（r=0．655，P〈0．01），可用公式TLV（m1）=12．5×SW（kg）＋536．4来表示。与已发表文章中的公式相比，ESLV与TLV的差异均有统计学意义（P〈0．05）。结论该研究建立了一个简单的更准确的预测中国成人标准肝体积的公式。

Objective To establish a favorable formula of estimation adult standard liver volume （SLV） based on the data of living donors for liver transplantation. Methods From March 2005 to December 2007,90 Adult-to-Adult living donor liver transplantation were performed. The donors＇ anthropometric data of gender, year, body weight and body height was collected prospectively. The total liver volume （ TLV ） of 90 living donors was measured by computed tomography. The correlation between TLV and several factors including body weight index （ BMI ） and body surface area （ BSA ） were analyzed. Then multiple stepwise linear regression analysis was performed and a new equation predicting SLV to improve approximate TLV was determined. TLV was then compared with the estimation standard liver volume （ESLV） calculated using our formula and published formulas in literature previously. Results All the subjects had a mean body weight of （62. 4 ±8. 7） kg. The mean total liver volume was （1319. 1 ± 167. 0） ml. There were positively correlated between TLV and body weight （BW）,which could be expressed in the equation： TLV（ml） = 12.5 × BW （kg） ＋ 536. 4（ r^2 = 0.43, P 〈 0. 01 ）. Compared TLV with ELSV, which were calculated using previously published formulas based on the anthropometric data of the 90 subjects, the difference was be statistically significant. Conclusion A new simple formula is established that might be a more suitable to calcuate TLV in Chinese adults.