凝血因子XⅢ缺乏导致术后颅内迟发血肿的诊断和治疗

Diagnosis and treatment of delayed intracranial hematoma after surgery induced by coagulation factor XⅢ deficiency

目的探讨凝血因子XⅢ缺乏症与开颅手术后颅内迟发血肿的关系。方法分析2例凝血因子XⅢ缺乏症导致手术后颅内迟发血肿患者的临床资料．并与同时期58例非凝血因子XⅢ缺乏症开颅手术后出现颅内迟发血肿患者的病历资料做对照．总结凝血因子XⅢ缺乏症导致手术后颅内迟发血肿病历的临床特点及规律．结果凝血因子XⅢ缺乏导致手术后颅内迟发血肿的特点是术后迟发血肿位于手术区域，且发病隐匿，病情进展快。结论术后出现迟发血肿病例要警惕凝血因子XⅢ缺乏的可能．如能及时诊治则患者预后良好。

Objective To investigate the relationship between coagulation factor XⅢ deficiency and delayed intracranial hematoma after craniotomy. Methods The clinical data of 2 cases with delayed intracranial hematoma induced by coagulation factor XⅢ after craniotomy were analyzed and compared with the data of 58 cases with delayed intracranial hematoma induced by other causes during the same period, so as to find out the clinical characteristics of the disease induced by coagulation factor XⅢ. Results The delayed intracranial hematoma induced by the deficiency in coagulation factor XⅢ was commonly located in the operative regions after surgery, and the process was insidious and fast. Conclusion When the delayed intracranial hematoma is confirmed after craniotomy, the deficiency in coagulation factor XⅢ should be taken into consideration. The prognosis will be satisfying if the diagnosis and treatment are in time.