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VEGF和Ang-1在急性脑缺血中的实验研究进展 被引量：4

Experimental research progress of VEGF and Ang-1 in acute cerebral ischemia
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摘要 动物实验和临床患者的研究均表明．急性脑缺血能诱导缺血区血管保护性增生．新生血管能够增加缺血半暗区氧气和营养物质的供应．因此急性脑缺血的治疗性血管增生是很有前景的治疗方法。大量研究也证明．应用外源性血管生成因子同样能促使缺血半暗区微血管生成．从而促进缺血后神经功能康复。缺血后血管生成是一个多因子参与调节的复杂过程．其中血管内皮生长因子（vascular endothelial growth factor．VEGF）和血管生成素-1（angiopoietin-1，Ang-1）在其中起关键作用．功能性成熟血管的形成有赖于这两类因子的协同作用．本文对近年来VEGF和Ang-1在急性脑缺血中的应用研究予以综述．
作者 李照建 王任直
机构地区 北京协和医院神经外科
出处 《中华神经医学杂志》 CAS CSCD 2008年第8期859-861,共3页 Chinese Journal of Neuromedicine
关键词 血管内皮生长因子 血管形成素-1 急性脑缺血 血管生成 Vascular endothelial growth factor Angiopoietin-1 Acute cerebral ischemia Angiogenesis
分类号 R743.31 [医药卫生—神经病学与精神病学]
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参考文献20

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同被引文献37

  • 1吴毓玲.养血清脑颗粒治疗缺血性脑血管病机制的探讨[J].黑龙江医学,2007,31(5):382-382. 被引量：3
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  • 3Longa EZ, Weinstein PR, Carlson S, et al. Reversible midge cerebral artery occlusion without craniectomy in rats[ Jl. Stroke, 1989, 20 : 84.
  • 4Menzies SA, Hoff JT, Betz AL. Middle cerebral artery oceiusion in rats: a neurological and pathological cvaluation of a reproducible model[J]. Neurosurgery, 1992, 31 : 100.
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  • 6Obrenovitch TP. Molecular physiology of preconditioning-induced brain tolerance to ischemia[ J]. Physiol Rev, 2008, 88: 211.
  • 7Laudenbach V, Fnntalne RH, Media F, et al. Neonatal hypoxic preconditioning involves vascular endothelial growth factor[ I]. Neuro Disc, 2007, 26: 243.
  • 8Mu D, Jiang X, Sheldon RA, et al. Regulation of hypoxia-induciblc factor 1alpha and induction of vascular endothelial growth factor in a rat neonatal stroke model[ J ]. Neurobiol Dis, 2003, 14: 524.
  • 9Vezzani A. VEGF as a target for neuroprotection [ J ]. Epilepsy Curt, 2008, 8:135.
  • 10Hansen TM, Moss AJ, Brindle NP. Vascular endothelial growth factor and angiopoietins in neurovaseular regeneration and protection following stroke[ J]. Curr Neurovasc Res, 2008, 5: 236.

引证文献4

二级引证文献16

中华神经医学杂志
2008年 第8期

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