十堰地区女性泌尿生殖道支原体感染状况及药物敏感性分析

Detection and evaluation of antibiotic susceptibility of ureaplasma urealyticum and mycoplasma hominis in Shiyan

目的:了解十堰地区女性泌尿生殖道支原体感染状况及其对药物敏感性的变化情况。方法:2006年1月-2007年12月妇科门诊1 568例女性泌尿生殖道感染患者,取宫颈分泌物进行解脲支原体(Uu)和人型支原体(Mh)的培养鉴定及药敏分析。结果:女性泌尿生殖道感染患者的支原体总感染率为43.5%(682/1 568)。解脲支原体单独感染447例,人型支原体单独感染88例,解脲支原体和人型支原体混合感染147例。对8种药物药敏试验结果表明,解脲支原体对多西环素、交沙霉素及米诺环素敏感率较高,分别为85.4%、79.8%和78.3%,对阿奇霉素及氧氟沙星的耐药率较高,其敏感率仅为30.8%、25.8%。结论:支原体混合感染的耐药性呈上升趋势;多西环素、交沙霉素及米诺环素是治疗女性泌尿生殖道支原体感染的首选药物,有条件的医疗机构应常规进行支原体培养及药敏分析。

Objective To investigate the infections in urogenital tract and changing trend of drug susceptibility of mycoplasma in Shiyan area.Methods Ureaplasma ruealyticum and mycoplasma hominis were detected in 1 568 cases of urogenital tract infection,and the susceptibility of clinical strains to antibiotics was determined with mycoplasma IST kit.Results The total positive rate of mycoplasma infection of female was 43.5%.447 cases were infected by ureaplasma ruealyticum,88 cases were infected by mycoplasma hominis and 147 cases were positive with both species.Doxymycin, josamycin and minomycin were the most active agents against ureaplasma ruealyticum strains.The azitromvcin and ofloxacin showed a high resistance rate.Conclusion Mixed infection and increasing resistance of mycoplasmas is a serious problem.Multiple resistances to two or more antibiotics are frequent.Mycoplasma is a predominant pathogen in female genitourinary tract infection,and it is sensitive to doxymycin,josamycin and minomycin.The resistance monitoring of mycoplasma periodically has an important significance in clinical practices.