摘要
目的探讨还原型谷胱甘肽(GSH,阿拓莫兰粉针剂)治疗慢性乙型肝炎的疗效及其对细胞因子的影响,并探讨其保护肝细胞的机制。方法104例慢性乙型肝炎患者随机分为两组:治疗组用GSH1200mg溶入5%葡萄糖液100mL,静脉滴注,1次/d;对照组用肌苷注射液0.4g加入5%葡萄糖液250mL,静脉滴注,1次/d。两组疗程均为4～8周。比较两组治疗后肝功能和肿瘤坏死因子(TNF-α)、白介素6(IL-6)、白介素8(IL-8)指标的变化。结果疗程结束时,治疗组TNF-α、IL-6、IL-8的降幅明显高于对照组(P<0.05和P<0.01);治疗组血清谷丙转氨酶(ALT)、血清谷草转氨酶(AST)、血清总胆红素(TBiL)、血清结合胆红素(DBiL)、总胆汁酸(TBA)的改善明显高于对照组(P<0.05)。结论GSH有明显的抑制细胞因子对肝脏的炎症反应,对慢性乙型肝炎有显著的治疗作用。
Objective To investigate the efficiency of treating chronic hepatitis B by GSH and the influence to cytokines, and discuss its system on protecting hepatocyte. Methods 104 patients with chronic hepatitis B were randomly divided into two groups. The treatment group： 1 200 mg GSH with 100 ml of 5% glucose, intravenous drip, once a day. The control group： 0.4 g inosine injection with 250 ml of 5% glucose, intravenous drip, once a day. The course of treatnient on the two groups are both 4 - 8 weeks. Compare the index changes of liver function, TNF-α, IL-6 and IL-8 after the treatment. Results At the end of the treatment amplitude reduction of TNF-α, IL-6 and IL-8 in treatment group is significantly higher than those of the control group （ P 〈 0.05, P 〈 0.01 ）. The improvement of AI,T, AST, TBiL, DBiL and TBA in treatment group is significantly higher than those of the control group （ P 〈 0.05 ）. Conclusion GSH takes a significant effect on chronic hepatitis B, which can restrain cytokines from inflammation to liver.
出处
《透析与人工器官》
2008年第2期25-28,共4页
Chinese Journal of Dialysis and Artificial Organs
