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Notch信号通路异常和肿瘤的生成 被引量：2

Abnormal Notch Signal Pathway and Carcinogenesis
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摘要 近年研究表明,Notch信号通路与肿瘤发生有关,但Notch对肿瘤的发生、发展可以起着截然相反的作用。在某些组织中Notch单个或多个成员具有显性癌基因作用,而在另一些组织量则发挥着抑癌基因的功能。本文就Notch在肿瘤研究中的研究进展作以综述。 In recent years,more and more studies have indicated that Notch pathway is related with tumors. But Notch may take an opposite effect on different tumors. Single or multiple members of Notch in some tissues can activate the development of tumors, but in other tissues Notch is an anti-oncogene. In this paper the author makes an overview to Notch in tumor studys.
作者 裘明哲 浦佩玉
机构地区 天津医科大学总医院神经外科天津市神经病学研究所神经肿瘤实验室
出处 《透析与人工器官》 2008年第2期32-36,共5页 Chinese Journal of Dialysis and Artificial Organs
关键词 信号通路 肿瘤 signal pathway neoplasms
分类号 R730.59 [医药卫生—肿瘤]
  • 相关文献

参考文献25

  • 1孙力,詹启敏,章文华.Notch信号通路与肿瘤[J].国外医学（肿瘤学分册）,2004,31(9):655-658. 被引量：11
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二级参考文献24

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  • 10Ellisen LW, Bird J, West DC, et al. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell, 1991,66 ( 4 ): 649-661.

共引文献10

同被引文献29

  • 1马道新,纪春岩,赵建强,郭农建,张茂宏,于书彦.高表达Delta4增加Notch基因的表达[J].基础医学与临床,2004,24(6):651-656. 被引量：2
  • 2杨志芳,易继林,李兴睿,谢大兴,廖晓锋,马昕.PTEN在HepG2细胞中诱导凋亡发生及上调p53表达[J].中华肝脏病杂志,2004,12(12):745-748. 被引量：4
  • 3芮红兵,苏津自,卓光生,康日辉,林珺芳.抑癌基因c与p53抑制白血病细胞株生长作用的比较[J].白血病．淋巴瘤,2007,16(1):15-18. 被引量：5
  • 4Suwanjunee S, Wongchana W, Palaga T. Inhibition of gamma-secretase affects proliferation of leukemia and hepatoma cell lines through Notch signaling [ J ]. Anti Cancer Drugs, 2008,19 ( 5 ) : 477 -486.
  • 5Fan X, Mikolaenko I, Elhassan I, et al. Notchl and Notch2 have opposite effects on embryonal brain tumor growth [ J ]. Cancer Res, 2004,64 ( 21 ) :7787-7793.
  • 6Mummery-Widmer JL, Yamazaki M, Stoeger T, et al, Genome-wide analysis of Notch signalling in Drosophila by transgenie RNAi[J].Nature, 2009,458 ( 7941 ) : 987-992.
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透析与人工器官
2008年 第2期

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