期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

缺氧诱导因子1α及其靶基因对脑缺氧缺血/再灌注损伤的调控作用 被引量：1

Control Cction of Hypoxia-Inducible Factor-1α and Target Genes in Hypoxia/Ischemia/Reperfusion Brain Damage
下载PDF
导出
摘要 缺氧诱导因子1α(HIF-1α)是一种具有转录活性的核蛋白,能与靶基因结合并通过转录和转录后调控,产生相应的生物活性,使机体在缺血缺氧时产生适应性反应。近年研究发现,HIF-1α和其靶基因对脑组织缺氧缺血/再灌注损伤具有重要意义。 Hypoxia inducible factor-1α （ HIF-1α ）, a nuclear protein with transcription activity, producing biological activity respectively. Can make body produce adaptive response to hypoxia/ischemia by binding to target genes, transcription and posttranscriptional control. The recent studies have found that the expression of HIF-1α and its target genes may contribute to the tolerance in hypoxia/ischemia/reperfusion brain damage.
作者 杨云 周名雄
机构地区 皖南医学院弋矶山医院儿科
出处 《医学综述》 2008年第16期2419-2421,共3页 Medical Recapitulate
关键词 缺氧诱导因子1Α 靶基因 脑缺氧缺血/再灌注损伤 Hypoxia inducible factor-1α Target genes Hypoxia/ischemia/reperfusion brain damage
分类号 R742 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献23

  • 1Semenza GL. HIF-1 : Mediator of physiological and pathophysiological responses to hypoxia [ J ]. Appl Physiol, 2000, 88 ( 4 ) : 1474 -1480.
  • 2Gu YZ, Moran SM, Hogenesch JB,et al. Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha [ J]. Gene Expr, 1998,7 ( 3 ) : 205-213.
  • 3LidenT, Katschinski DM, Eckhardt K, et al. The antimycotic ciclopirox olamine induces HIF-la stability, VEGF expression, and angiogenesis [ J ]. FASEB J,2003,17 ( 6 ) :761-763.
  • 4Lando D, Peet DJ, Gorman JJ, et al. FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor[ J ]. Genes Dev,2002,16 ( 12 ) : 1466-1471.
  • 5Corley KM, Taylor CJ, Lilly B. Hypoxia-inducible factor 1alpha modulates adhesion, migration, and FAK phosphorylation in vascu- lar smooth muscle cells[ J]. Cell Biochem,2005,96(5 ) :971-985.
  • 6Papandreou I, Cairns RA, Fontana L,et al. HIE-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption[ J]. Cell Metab,2006,3 ( 3 ) : 187-197.
  • 7Cramer T,Yam anishi Y, Clausen BE,et al. HIF-lalpha is essential form yeloid cell mediated inflammation [ J ]. Cell, 2003,112 ( 5 ) : 645 -657.
  • 8Baranova O, Miranda LF, Pichiule P, et al. Neuron-specific inactivation of the hypoxia inducible factor 1α increases brain injury in a mouse model of transient focal cerebral ischemia [ J ]. Neurosci, 2007,27 (23) :6320-6332.
  • 9Ahhaus J, Bemaudin M, Petit E ,et al. Expression of the gene encoding the proapoptotic BNIP3 protein and stimulation of hypoxia-inducible factor-1 alpha protein following focal cerebral ischemia in rats [ J ]. Neurochem Int ,2006,48 ( 8 ) :687-695.
  • 10Sandau US ,Handa RJ. Localization and developmental ontogeny of the pro-apoptotic Bnip3 mRNA in the postnatal rat cortex and hippocampus [ J ]. Brain Res, 2006,1100 ( 1 ) :55-63.

二级参考文献34

  • 1季淑梅,薛建梅,王川,苏素文,何瑞荣.肾上腺髓质素降低培养海马神经元胞内游离钙离子浓度(英文)[J].生理学报,2005,57(3):340-345. 被引量：3
  • 2中华医学会儿科学分会新生儿学组.新生儿缺氧缺血性脑病诊断标准[J].中华儿科杂志,2005,43(8):584-584. 被引量：1298
  • 3张士发,周名雄,张新路,杨军,窦常胜,李志奇.新生儿HIE血浆ADM动态水平及临床意义[J].放射免疫学杂志,2005,18(6):419-421. 被引量：8
  • 4陈社菊,杨静丽,冯红旗.综合指标早期评估新生儿缺氧缺血性脑病的预后[J].实用儿科临床杂志,2006,21(23):1665-1665. 被引量：7
  • 5Gashler A, Sukhatme V P. Early growth response proteinl (Egr- 1):prototype of a zinc -finger family transcription factors[J]. Prog Nucleic Acid Res Mol Biol,1995,50:191 -224.
  • 6Hu R M, Ellis R L. Astrocytes growth is regulated by neuro- peptides through Tis8 and basic fibroblast growth factor[J]. J Clin Invest, 1994,93:820 - 827.
  • 7Liu C,Calogero A,Ragona G. et al. EGR- 1 ,the reluctant suppression factor:EGR- 1 is known to function in the regulation of growth, differentiation, and also has significant tumor suppressor activity and a mechanism involving the induction of TGF- beta 1 is postulated to account for this suppressor activity[J]. Cric Rev Oncog, 1996,7(1 - 2):101 - 125.
  • 8Cheng Y, Deshmukh M, D'Costa A, et al. Caspase inhibitor affords neuroprotection with delayed administration in a rat model neonatal hypoxic- ischemic brain injury [J]. J Clin Invest, 1998,101 (9) :1992 -1999.
  • 9Dogan A, Suzuki Y, Koketsu N, et al. Intravenous infusion of adrenomedullin and increase in regional cerebral blood flow and prevention of ischemic brain injury after middle cerebral artery occlusion in rats [J]. J Cereb Blood Flow Metab, 1997,17 ( 1 ):19 - 25.
  • 10Wang X, Yue T, Barone F C,et al. Discovery of adrenomedullin in rat ischemic cortex and evidence for its role in exacerbating focal brain ischemic damage [J]. Proc Natl Acad Sci USA, 1995, 92(25):11480 - 11484.

共引文献9

同被引文献3

引证文献1

二级引证文献4

医学综述
2008年 第16期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部