摘要
机体内一氧化氮(NO)是左旋精氨酸(L-arginine)与氧气经一氧化氮合酶(NOS)作用而产生的一种活性气体,适当浓度的NO可通过NO-cGMP途径调控心肌细胞ATP敏感性钾通道(KATP)的功能,调节心肌细胞对组织缺血缺氧的耐受性,参与心肌细胞的自身保护机制。NO生成不足与高血压、动脉粥样硬化、心力衰竭、糖尿病、高脂血症等心血管疾病的发生有关;NO生成和释放增多也可直接参与多种疾病的发生和发展,即NO与心功能密切相关,对多种疾病有重要的病理生理作用和临床意义。
NO is an important active gas in the body, which is produced by L-arginine and oxygen catalized by NOS. Moderate concentration of NO could regulate the function of KATP in the myocardial cells through NO-cGMP pathway,improve the tolerance of myocardial cell to hypoxia and prevent cell from damage. Deficiency of NO is related to the cardiovascular diseases such as hypertension, atherosclerosis, heart failure, diabetes and hyperlipidemia; Overloaded NO could also induce or aggravate many diseases. All above showed that NO have significant effect on cardiac function, which play an important role in pathophysiology in some diseases and clinic.
出处
《医学综述》
2008年第16期2422-2424,共3页
Medical Recapitulate
关键词
一氧化氮
ATP敏感性钾通道
心肌细胞
Nitrlc oxide
ATP-sensitive potassium channel
Myocardial cells
