血清尿酸水平与冠心病相关性研究

Study on the relationship between the level of serum uric acid and coronary heart disease

目的探讨血清尿酸水平与冠心病(CHD)发病的相关性。方法收集214例CHD患者和200例健康对照者资料,检测血尿酸(SUA)、空腹血糖(FPG)和血脂等指标,记录年龄、性别、血压、身高、体重,计算体质指数(BMI)。结果与非CHD组比较,年龄、性别、血压、FPG、血脂(TC、TG、LDL-C和HDL-C)、BMI、SUA在CHD组的分布差异具有统计学意义,P<0.05。Logistic回归分析结果表明性别、糖尿病、高血压、CHD家族史为CHD发生的独立危险因素。高血压、高血糖、TG≥1.7 mmol/L、BMI、SUA≥416μmol/L在单纯CHD组和CHD-MS组中的分布差异具有统计学意义,P<0.05。结论SUA水平是CHD发病的危险因素;但不构成独立危险因素;有代谢综合征的CHD患者血清尿酸水平更易升高。

Objective To study the relationship between the serum uric acid level and coronary heare disease（CHD）.Methods A total number of 214 CHD patients hospitalized in the department of cardiovascular medicine and 200 healthy controls recruited by random sampling were investigated by case-control studied.In all subjects,SUA,TG,TC,HDL,LDL-C and FPG were detected,blood pressure,body height,body mass were measured,body mass index（BMI） was calculated.Results Between control group and CHD group,the differences of age,sex,blood pressure,SUA,TG,TC,HDL,LDL-C and FPG distribution reached statistics significance,P〈0.05.Logistic regression analys shows that sex,diabetes,hypertension and the family history of CHD were independent risk factors for the prevalence of CHD.Between CHD group and CHD-MS group,the differences of hypertension,hyperglycaemia,TG≥1.7 mmol/L,BMI,SUA≥416 μmol/ L distribution reached statistics significance,P〈0.05.Conclusion The level of SUA is a risk factor for CHD,but not an independent risk factor.The level of SUA in CHD patients with metabolic syndrome is easier high.