慢性阻塞性肺疾病急性加重期凝血功能检测的临床意义

Function changes of coagulation system in acute exacerbation of chronic obstructive pulmonary disease

目的探讨慢性阻塞性肺疾病(COPD)急性加重期凝血功能的变化。方法对78例COPD急性加重期患者、55例COPD稳定期患者和20例健康体检者检测4项凝血(PT、APTT、TT、Fbg)和D-二聚体,用SPSS14.0软件进行单因素方差分析。结果急性加重期患者Fbg和D-二聚体含量显著高于稳定期患者和正常对照组,稳定期含量也明显高于正常对照组(P<0.05),PT、APTT、TT含量在三组间差异无统计学意义(P>0.05)。结论对COPD患者进行监测Fbg和D-二聚体水平,有助于采取有效的防治措施,可控制病情的发展,改善疾病的预后。

Objective To study the function changes of coagulation system in patients with acute exacerbation of chronic obstructive pulmonary disease（ AECOPD）. Methods The vein blood samples were taken from 78 COPD cases at acute exacerbation cases ,55 stable period cases and 20 normal controls for the detemination of 4 indexes of coagulation （PT, APTT, TT, Fbg） and D - dimer. One - way ANOVA was used by SSPS 14.0. Results Fbg and D - dimer level were significantly different between acute exacerbation and stable COPD patients and nomal controls （ P 〈 0. 05 ） , but PT, APTT and TT level were not significantly different in three groups （ P 〉 0.05 ）. Conclusion Fbg and D - dimer level are detected for COPD patients to be benefit to take effective treatments and control development and improve prognosis.