P_(53)基因蛋白在子宫内膜癌中的表达及其临床意义

Clinical Correlations of P53 Protein Expression in Endometrial Carcinoma

为了研究Ｐ５３基因突变与子宫内膜癌的关系，本研究应用免疫组化Ｓ－Ｐ法检测了６４例子宫内膜癌，１６例正常子宫内膜，３２例子宫内膜增殖症及５例子宫内膜息肉组织中Ｐ５３蛋白表达情况。结果：突变型Ｐ５３蛋白在子宫内膜癌组织中的阳性率为３７．５％，而在正常子宫内膜、子宫内膜单纯性及复合性增生、内膜息肉中均阴性，不典型增生１例（１／３）阳性。突变型Ｐ５３阳性表达与临床分期、组织学级别相关，与病理类型、肌层浸润无关。Ｐ５３阳性表达患者的３年、５年生存率明显低于阴性患者（Ｐ＜０．０１）。认为突变型Ｐ５３与子宫内膜癌恶性生物学行为相关。

objective:To study the clinical correlations of P53 gene mutation in endometrial carcinomaMethods:Expression of P53 Protein was studied by immunohistochemistry in Paraffin sections from 64 patients with endometrial carcinoma,16 patients with normal endometrium,32 patients with endometrium hyperplasia and 5 patients with endometrium PolypResult:(1)P53 Protein was positive in 375% of patients with endometrial carcinoma,but engative in patients with normal endornetrium,patients with simple hyperplasia, patients with complex hyperplasia and patients with endometrial Polyp,1 Positive in 3 patients with atypical hyperpalsia(2)In endometrium Carcinoma,P53 Overexpression was significantly associated with clinical stage (P<005),histologic grade(P<0001),not with pathological type,muscle invasion(P>005)(3)The survival rate in patients with P53 Overexpression is significantly lower than that in patients without itConclusion:there was closely relationship between the P53 overexpression and the degree of malignancy. Overexpression is indicator of poor prognosis