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骨髓增生异常综合征异常克隆与细胞形态的关系 被引量：5

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摘要 尽管细胞遗传学异常逐渐成为骨髓增生异常综合征（MDS）诊断、分型、预后判断的要素之一，血细胞发育异常的细胞形态学改变仍然是诊断MDS的一个必要条件，无论是FAB分型还是WHO分型都是在细胞形态学的基础上进行的。MDS的细胞遗传学、分子生物学特征已日益清晰，但是MDS异常克隆与造血细胞形态改变的关系仍不清楚。我们应用标尺定位Wright-Giemsa染色的骨髓细胞涂片，通过荧光原位杂交（FISH）技术，探讨MDS异常克隆与细胞形态（病态造血细胞与非病态造血细胞）的关系。
作者 秦玲 王椿 白萍 秦尤文 王小蕊 颜式可 高彦荣 蔡琦 赵初娴 蒋瑛
机构地区 上海交通大学附属第一人民医院血液科
出处 《中华血液学杂志》 CAS CSCD 北大核心 2008年第8期564-566,共3页 Chinese Journal of Hematology
关键词 骨髓增生异常综合征 细胞形态学改变 Wright-Giemsa染色 克隆 细胞遗传学异常 病态造血细胞 血细胞发育异常 分子生物学特征
分类号 R686 [医药卫生—骨科学]
  • 相关文献

参考文献10

  • 1Vardiman JW, Harris NL, Brunning RD. The World Health Organization (WHO) classification of the myeloid neoplasms. Blood, 2002, 100:2292-2302.
  • 2Jaffe ES, Harris NL, Stein H, et al. World Health Organization classification of tumours: pathology and genetics of tumours of haematopoietic and lymphoid tissues. Lyon: IARC Press, 2001 : 61-73.
  • 3Germing U, Gattermann N, Strupp C, et al. Validation of the WHO proposals for a new classification of primary myelodysplastic syndromes: a retrospective analysis of 1600 patients. Leuk Res, 2000,24:983-992.
  • 4蔡宇,秦尤文,王椿,杨隽,颜式可.荧光原位杂交技术检测骨髓增生异常综合征患者5、7、8号染色体异常及临床意义[J].中华血液学杂志,2007,28(1):6-10. 被引量：4
  • 5Godon C, Talmant P, Garand R, et al. Deletion of 5q31 is observed in megakaryocytic cells in patients with myelodysplastic syndromes and a del (5q), including the 5q - syndrome. Genes Chromosomes Cancer, 2000, 29:350-352.
  • 6Bigoni R, Cuneo A, Milani R, et al. Muhilineage involvement in the 5q - syndrome: a fluorescent in situ hybridization study on bone marrow smears. Haematologica, 2001, 86:375-381.
  • 7Hast R, Eriksson M, Widell S, et al. Neutrophil dysplasia is not a specific feature of the abnormal chromosomal clone in myelodysplastic syndromes. Leuk Res, 1999, 23: 579-584.
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  • 10Northup JK, Gadre SA, Ge Y, et al. Do cytogenetic abnormalities precede morphologic abnormalities in a developing malignant condition? Eur J Haematol, 2007,78 : 152-156.

二级参考文献7

共引文献3

同被引文献45

  • 1邱镜滢,赖悦云,柴晔,张艳,师岩,何琦,党辉,陆道培.306例骨髓增生异常综合征染色体核型的研究[J].中国实验血液学杂志,2004,12(4):455-459. 被引量：32
  • 2陈苏宁,薛永权,吴亚芳,潘金兰.一例伴有t(6;11)(q27;q23)的急性单核细胞白血病患者的遗传学研究[J].中华血液学杂志,2004,25(8):494-495. 被引量：7
  • 3王珈.骨髓增生异常综合征30例分析[J].临床和实验医学杂志,2006,5(7):1024-1025. 被引量：1
  • 4Vardiman JW, Harris NL, Brunning RD. The World Health Organization( WHO ) classification of the myeloid neoplasms. Blood, 2002,100:2292-2302.
  • 5Shaffer LG, Tommerap N. ISCN 2005: an international system for human cytogenetic nomenclature. Basel: Karger, 2004.
  • 6Jaffe ES, Harris NL, Stein H, et al. World Health Organization classfication of tumours of haematopoietic and lymphoid tissues. Lyon : IARC Press, 2001:61-73 .
  • 7Chert Z, Morgan R, Stone JF, et al. Fish: a useful technique in the verification of clonality of random chromosome abnormalities. Cancer Genat Cytogenet, 1993,66:73-74.
  • 8van Lom K, Houtsmuller AB, van Putten WL, et al. Cytogenetie clonality analysis of megakaryocytes in myelodysplastic syndrome by dual-color fluorescence in situ hybridization and confocal laser scanning microscopy. Genes Chromosomes Cancer, 1999,25:332- 338.
  • 9Bigoni R, Cuneo A, Milani R, et al. Multilineage involvement in the 5q - syndrome: a fluorescent in situ hybridization study on bone marrow smears. Haematologica, 2001, 86:375-381.
  • 10Godon C, Talmant P, Garand R, et al. Deletion of 5q31 is observed in megakaryocytic cells in patients with myelodysplastie syndromes and adel (5q) , including the 5q - syndrome. Genes Chromosomes Cancer, 2000, 29:350-352.

引证文献5

二级引证文献35

中华血液学杂志
2008年 第8期

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