子宫内膜癌组织中微血管表达及临床意义

Expression of microvessel density in endometrial carcinoma and its clinical significance

目的探讨子宫内膜癌组织中微血管生成状况及临床意义。方法采用免疫组化方法,用CD34标记血管内皮细胞并计算8例增生期子宫内膜组织、15例不典型增生子宫内膜组织及20例子宫内膜癌组织中的微血管密度值,并分析其与主要临床病理参数关系。结果①增生期子宫内膜、不典型增生子宫内膜及子宫内膜癌组织中微血管密度值(MVD)呈逐渐增高趋势,计数值分别为8.3±3.4,18.5±4.3及31.6±5.5,各组间差异有统计学意义;②子宫内膜癌高及中-低分化组织MVD值分别为26.3±4.4及32.3±5.4,两组间差异无统计学意义;③子宫内膜癌FIGOⅠ期、Ⅱ-Ⅳ期的MVD值分别为23.7±4.3及46.0±3.7,差异有统计学意义。结论血管生成在子宫内膜癌组织的发生、发展中起重要促进作用。

Objective To explore the angiogenesis in endometrial carcinoma and its clinical significance. Methods Immunohistochemical method was used to determine microvessel density（MVD）in 8 cases of proliferative endometrium, 15 cases of atypical hyperplasia endometrium and 20 cases of endometrial carcinoma. Results （1）MVD were 8.3 ± 3.4,18.5 ± 4.3,31.6 ± 5.5 in proliferative endometrium, atypical hyperplasia endometrium and endometrial carcinoma, respectively, and there was significant difference between 3 groups. （2）Of endometrial carcinoma, MVD were 26.3±4.4,32.3 ± 5.4 in grade I and grade 2 - 3, respectively（ P 〉 0.05）. （3）InFIGOstage Ⅰ andstage Ⅱ-Ⅳ,MVDwere23.7±4.3and46.0±3.7,respectively（P〈0.05）. Conclusion Angiogenesis plays an important role in the development of endometrial carcinoma.