盐酸格拉司琼鼻用温敏型凝胶的制备及其体外释放度研究

Preparation of Granisetron Hydrochloride Nasal Thermosensible Gels and Its Release Behavior In vitro

目的研制盐酸格拉司琼鼻用温敏型凝胶并考察其体外释药行为。方法以泊洛沙姆407为凝胶材料,泊洛沙姆188及聚乙二醇6000调节胶凝温度,正交试验法优选处方,并采用数学模型拟合体外释放曲线。结果盐酸格拉司琼鼻用温敏型凝胶在32～33℃胶凝,体外释药行为符合Higuchi方程。结论盐酸格拉司琼鼻用温敏型凝胶处方设计合理,可进一步研究开发。

Objective To prepare granisetron hydrochloride nasal thermosensible gels and to study the release mechanism in vitro. Methods The formulations were screened by the application of P407 as the gel matrix. P188 and PEG6000 were used to adjust the gelatination temperature by the method of orthogonal test. Mathematic the mathematical models were used to imitate the drug mechanism in vitro. Results The granisetron hydrochloride nasal thermosensible gels could he gelated at the temperature between 32-33℃ and the dissolution curves in vitro showed that the drug release could he best described by the Higuchi equation. Conclusion The formula of granisetron hydrochloride nasal thermosensihle gels is reasonable and it is worth doing further research.