抗精神病药物对精神分裂症患者肝功能的影响

The influence of antipsychotic drug on liver function of schizophrenia patients

目的探讨抗精神药对精神分裂症患者肝功能的影响。方法对86例精神分裂症患者进行随机分组,一组用经典抗精神病药氯丙嗪治疗,另一组用非典型抗精神病药利培酮治疗,对血清中肝功能各项指标进行抗精神病药治疗前、治疗后4周和治疗后8周的比较。结果精神分裂症患者的肝功能在治疗4周后明显异常,非典型性抗精神病药物对肝功能的影响明显小于经典抗精神病药,差异有统计学意义。结论抗精神病药物可引起肝功能异常,非典型抗精神病药物对患者机体肝功能的损害较轻。

Objective To explore the Influence of antipsychotic drug on liver function of schizophrenia patients. Methods Eighty-six schizophrenia patients were randomly divided into two groups. One group received the treatment of typical antipsychotic drug （chlorpromazine）, another received the treatment of atypical antipsychotic drug （risperidone）, The indexes of liver function in all patients were compared respectively before the treatment, after 4 and 8 weeks of treatment. Results Liver function in the patients of schizophrenia group became remarkably abnormal after four weeks of treatment. The influence of atypical antipsychotic drug on liver function was lower than typical antipsychotic drug, There was significant difference between them. Conclusion Antipsycbetic drug can cause liver function to be abnormal. Patients＇s liver function damage caused by atypical antipsychofic drug is lower.