用多聚酶链反应诊断早产、死胎及先天畸形儿巨细胞病毒感染

Diagnosis of Cytomegalovirus Infection in the Cases with Premature, Stillbirth and Congenital Teratosis by Polymerase Chain Reaction

采用多聚酶链反应（ＰＣＲ）技术检测７２例早产、死胎及先天性畸形儿尸解石蜡包埋标本中的巨细胞病毒ＤＮＡ，阳性率６．９４％；５例阳性者中，双胎宫内死亡２例，先天性畸形２例，脑积水１例。结果提示异常妊娠和先天畸形的发生与巨细胞病毒感染有关。文中讨论了多聚酶链反应诊断巨细胞病毒感染的价值。

he cytomegalovirus DNA was detected in the paraffin-embedded tissues of 72 autopsy cases with premature,stillbirth and teratic fetuses or infants by polymerase chain reaction.The result showed that the positive rate was 6.94 percent.Among the 5 positive cases,there were 2 cases of twin stillbirth,2 cases of congenital malformation and one case of hydrocephalus.This finding indicated that the cytomegalovirus infection may be related to the abnormal birth and congenital teratosis.The clinical significance of polymerase chain reaction for the diagnosis of cytomegalovirus infection was discussed in the context.