脊髓的可塑性

Spinal Cord Plasticity (review)

脊髓损伤后,脊髓的可塑性由损伤和特殊形式的训练启动,表现为自发性可塑性(损伤诱导的可塑性)和训练任务依赖性可塑性两种类型。自发性可塑性主要表现为轴突芽生、潜伏通路重启、突触效率改变等形式;训练任务依赖性可塑性表现为中枢模式发生器重新激活、脊髓神经元回路重组。对脊髓可塑性的深入探索、最大限度地增强脊髓的可塑性,将有助于优化现有治疗方案或研究新的治疗策略,进一步促进脊髓损伤患者的康复。

Spinal cord plasticity includes spontaneous neuronal plasticity and task-dependent plasticity which was respectively driven by spinal cord injury and special treatment.Spontaneous plasticity occurred at neuronal and synaptic sites,displaying various forms of axonal sprouting,unmasking of relatively ineffective functional connections and modification of synaptic efficacy.Task-dependent plasticity demonstrated reactivation of central generator pattern and functional reorganization of extensive spinal circuits.Exploration,induction and guidance of spinal cord plasticity will help determine the most optimal treatments and expand therapy methods to further promote function recovery of patients with spinal cord injury.