期刊文献+

阿司匹林抵抗的发生机制 被引量:5

Mechanism of Aspirin Resistance (review)
下载PDF
导出
摘要 阿司匹林作为预防性用药在血栓性疾病患者及其高危人群中已广泛应用,但部分患者尽管服用阿司匹林,却仍不能避免卒中等血栓性疾病的发生,由此,"阿司匹林抵抗"的概念被提出。笔者就阿司匹林抵抗机制进行综述。 Aspirin is widely used for the prophylaxis of ischemic events in patients with atherothrombotic complications or in populations with high risk of thrombotic events.However,despite the treatment of aspirin some patients experience thrombotic events,such as stroke.So the concept of "aspirin resistance" has been put forward.The mechanism of aspirin resistance is discussed in this article.
作者 程敏 郭淮莲
出处 《中国康复理论与实践》 CSCD 2008年第8期742-744,共3页 Chinese Journal of Rehabilitation Theory and Practice
关键词 阿司匹林抵抗 卒中 缺血 综述 aspirin resistance stroke ischemia review
  • 相关文献

参考文献21

  • 1Metha J, Metha P, Burger C, et al. Platelet aggregation studies in coronary arterydisease[J]. Atherosclerosis,1978,31:169-175.
  • 2Grotemeyer KH, Scharafinski HW, Husstedt IW. Two-year follow- up of aspirin responder and aspirin on-responder: a pilot-study including 180 poststroke patients[J]. Thromb Res,1993,71:397-403.
  • 3Awtry EH, Loscalzo J. Aspirin[J]. Circulation, 2000,101:1206-1218.
  • 4Patrono C, Coller B, Dalen JE, et al. Platelet active drugs: the relationships among dose, effectiveness, and side effects[J]. Chest, 2001,119:39S-63S.
  • 5Sztriha L, Sas K, Vecsei L. Aspirin resistance in stroke: 2004[J]. J Neurol Sci, 2005,229-230 : 163-169.
  • 6Harrison P. Screening for asipirin responsiveness[J]. Stroke,2005, 36:1001-1005.
  • 7Gum PAC, Kottke Marchant K, Poggio ED, et al. Profile and prevalence of aspirin resistance in patients with cardiovascular disease [J]. Am J Cardiol,2001,88:230-235.
  • 8辛晓敏,金英玉,张云平,关秀茹,李洁.阿司匹林抵抗与尿11-脱氢-血栓素B_2的检测及相关性研究[J].中华检验医学杂志,2005,28(9):919-921. 被引量:10
  • 9Eikelboom JW, Hirsh J, Weitz J, et al. Aspirin resistant thromboxane biosynthesis and the risk of myocardial infarction, stroke, or cardiovascular death in patients at high risk for cardiovascular events [J]. Circulation, 2002,105 : 1650-1655.
  • 10Patrono C, Coller B, Dalen JE, et al. Platelet-active drugs: the relationships among dose, effectiveness, and side effects[J]. Chest, 1998,114(Suppl 5):470S-488S.

二级参考文献27

  • 1[1]Chaturvedi S,Yadav JS.The role of antiplatelet therapy in carotid stenting for ischemic stroke prevention[J].Stroke,2006,37:1572-1577.
  • 2[2]Wenaweser P,D(o)rffler-Melly J,Imboden K,et al.Stent thrombosis is associated with an impaired response to antiplatelet therapy[J].J Am Coll Cardiol,2005,45:1748-1752.
  • 3[3]Lev EI,Patel RT,Maresh KJ,et al.Aspirin and clopidogrel drug response in patients undergoing percutaneous coronary intervention:the role of dual drug resistance[J].J Am Coll Cardiol,2006,47:27-33.
  • 4[4]Müller I,Besta F,Schulz C,et al.Prevalence of clopidogrel non-responders among patients with stable angina pectoris scheduled for elective coronary stent placement[J].Thromb Haemost,2003,89:783-787.
  • 5[5]North American Symptomatic Carotid Endarterectomy Trial Collaborators.Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis[J].N Engl J Med,1991,325:445-453.
  • 6[6]Cattaneo M.Resistance to antiplatelet drugs:molecular mechanisms and laboratory detection[J].J Thromb Haemost,2007,5 (Suppl 1):230-237.
  • 7[7]Nguyen TA,Diodati JG,Pharand C.Resistance to clopidogrel:a review of the evidence[J].J Am Coll Cardiol,2005,45:1157-1164.
  • 8[8]Müller I,Seyfarth M,Rudiger S,et al.Effect of a high loading dose of clopidogrel on platelet function in patients undergoing coronary stent placement[J].Heart,2001,85:92-93.
  • 9[9]Weerakkody GJ,Brandt JT,Payne CD,et al.Clopidogrel poor responders:an objective definition based on Bayesian classification[J].Platelets,2007,18:428-435.
  • 10[10]Dropinski J,Jakiela B,Sanak M,et al.The additive antiplatelet action of clopidogrel in patients with coronary artery disease treated with aspirin[J].Thromb Haemost,2007,98:201-209.

共引文献12

同被引文献53

引证文献5

二级引证文献14

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部