摘要
目的观察米氮平合并心理治疗对癫痫患者伴发抑郁障碍的疗效。方法将102例癫痫伴发抑郁障碍患者按入选顺序分为对照组和试验组,各51例,分别采用单纯米氮平治疗(对照组)和米氮平合并心理治疗(试验组),共6周,6个月后分别对两组患者进行随访观察,用汉密尔顿抑郁量表(HAMD)和临床疗效总评量表(CGI-SI)进行评定,对治疗副作用采用副反应量表(TESS)评定。结果治疗6周后及6个月后的随访显示,两组患者的HAMD和CGI-SI评分与治疗前比较差异均有显著性意义(P<0.05),试验组患者的HAMD和CGI-SI评分与对照组比较差异亦有显著性意义(P<0.05)。结论米氮平合并心理治疗对癫痫患者伴发抑郁障碍疗效明显。
Objective To investigate the effects of mirtazapine ccombined with psychological treatment on depression of patients with epilepsy.Methods 102 patients with epilepsy and complicated with depression were divided into the control group and trial group with 51 cases in each group.The control group received conventional mirtazapine and the trial group received mirtazapine combined with psychological therapy.The course was six weeks.The follow-up was performed six months after treatment and all patients were evaluated with Hamilton Depression Scale（HAMD）and Clinical Global Impression（CGI-SI）.The side effects were evaluated with Treatment Emergent Symptom Scale（TESS）.Results After the treatment of six weeks,the HAMD and CGI-SI scores of patients of the two groups significantly increased（P〈0.05）and the scores of the trial group increased more significantly than that of the cintrol group（P〈0.05）six months later.Conclusion The effect of mirtazapine combined with psychological therapy on depression of patients with epilepsy is obvious.
出处
《中国康复理论与实践》
CSCD
2008年第8期784-785,共2页
Chinese Journal of Rehabilitation Theory and Practice
关键词
癫痫
情感障碍
心理干预
疗效
epilepsy
affective disorder
psychological intervention
effect
