高压氧延长不同系小鼠皮肤移植存活时间及与移植局部浸润细胞的关系

The Effect of Hyperbaric Oxygen on Prolonging the SurvialTime of Skin Flaps in Mice by Inhibiting Local Lymphocyte Infiltration

观察Ｃ５７ＢＬ／６小鼠接受ＢＡＬＢ／ｃ小鼠皮肤移植后，在９９．２％氧，０．２５ＭＰａ条件下每天１ｈ，看到移植皮片存活时间明显延长；并动态观察了移植局部组织及浸润细胞情况。结果表明：高压氧可使移植局部组织破坏减轻，浸润细胞数量减少；使Ｔｈｙ－１，ＩＬ－２Ｒ（α）阳性细胞浸润荧光面积明显低于对照组。提示高压氧抑制移植局部细胞浸润，从而延长了移植物存活时间。

e observed the skin flaps in different strains of mice under the action of 99.2% oxygen with 0.25 MPa for one hour every day. Hyperbaric oxygen (HBO) prolonged the survivaltime of the skin flaps in mice significantly. On the third day, in one week, two week and three week after allograft, the infiltrative cells in the graft were much less in the hyperbaric oxygen group as compared with the control. Thy1 and IL2R(α) positive cell infiltration all decreased significently. Conclusion: HBO might prolong the survivaltime of skin flaps by inhibiting local lymphocyte infiltration. 