蒎酮酰胺衍生物的合成

Synthesis of pinonamides

以α-蒎烯为原料、水为反应溶剂、高锰酸钾为氧化剂合成了2-（3-乙酰基-2，2-二甲基环丁基）乙酸（即蒎酮酸），蒎酮酸的收率为50％。蒎酮酸与氯化亚砜反应生成酰氯，再与取代芳胺反应生成了6种蒎酮酰胺衍生物，产品收率介于40．4％～69．9％之间。

2-（3-Acetyl-2,2-dimethylcyclobutyl）acetic acid（ pinonic acid） is synthesized using α-pinene as raw materials, water as the reaction solvent and potassium permanganate as oxidant. The yield of pinonic acid can be up to 50%. Six kinds of N-aryl pinonamides are prepared through the reaction of aryl amine with 2-（3-acetyl-2, 2-dimethylcyclobutyl）acetyl chloride which is prepared from pinonic acid and thionyl chloride. The yields of the amides are between 40.4% -69.9%.