非甲—戊型病毒性肝炎患者血清庚型肝炎病毒感染的研究

Hepatitis G Virus Infection in Patients with Non A-E Hepatitis

采用ＥＬＩＳＡ法及逆转录—ＰＣＲ（简称ＲＴ—ＰＣＲ）法检测３６例非甲—戊型肝炎患者血清庚型肝炎病毒抗体（简称抗ＨＧＶ）和庚型肝炎病毒（简称ＨＧＶＲＮＡ）。结果：７例（１９．４％）抗ＨＧＶ阳性，２例（５．４％）同时ＨＧＶＲＮＡ阳性；急性肝炎抗ＨＧＶ阳性者临床表现与抗ＨＧＶ阴性者无显著差异，慢性肝炎抗ＨＧＶ阳性者较抗ＨＧＶ阴性者轻。提示：ＨＧＶ可引起急、慢性肝炎，在非甲—戊型肝炎中占有一定比例，但不是主要原因。

o elucidate the role of hepatitis G virus(HGV) infection in acute or chronic Non A-E hepatitis, we studied HGV infection in 36 acute or chronic Non A-E hepatitis by ELISA and retro-nested PCR. Results: (1) 4 of 25 patients with acute Non A-E hepatitis were positive for anti-HGV (15%) and negative for HGV RNA. Among acute cases no obvious difference was found about their clinical manifestations between these anti-HGV positive and negative conditions. (2) 3 of 11 patients with chronic Non A-E hepatitis were positive for anti-HGV (27.3%) and 2 of 3 were positive for HGV RNA. Their clinical manifestations were milder than other chronic hepatitis. HGV infection was not the main cause of Non A-E hepatitis, but it played some role. Among the 7 anti-HGV(+) patients, none had a history of transfusion, surgery or IV administration of drugs. HGV may be transmitted by other way. The rate of anti-HGV was higher than that of HGV RNA. So far, the reason has not been found.