脂蛋白代谢紊乱的遗传基础

Genetic Basis of Lipoprotein Disorders

脂蛋白代谢紊乱的遗传基础赵庆伟佘铭鹏（中国医学科学院基础医学研究所、中国协和医科大学基础医学院，北京１００００５）ＡｂｓｔｒａｃｔＬｉｐｏｐｒｏｔｅｉｎｄｉｓｏｒｄｅｒｓｒｅｓｕｌｔｆｒｏｍａｂｎｏｒｍａｌｓｙｎｔｈｅｓｉｓ，ｐｒｏｃｅｓｓｉｎｇ，ｏ...

Lipoprotein disorders result from abnormal synthesis,processing,or catabolism of plasma lipoprotein particles.A number of studies indicate the presence of genetic factors that accelerate ageassociated cardiovascular changes seen in general population.Four types of lipoprotein abnormalities are observed:elevated LDL cholesterol;reduced HDL cholesterol,usually with increased triglycerides and verylowdensity lipoprotein(VLDL) cholesterol;elevated levels of chylomicron rennants and intermediatedensity lipoproteins(IDL);and elevated levels of lipoprotein(a)〔Lp(a)〕particles.Lipoprotein transport genes have been implicated in each of these abnormal lipoprotein phenotypes.