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脂蛋白代谢紊乱的遗传基础 被引量:1

Genetic Basis of Lipoprotein Disorders
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摘要 脂蛋白代谢紊乱的遗传基础赵庆伟佘铭鹏(中国医学科学院基础医学研究所、中国协和医科大学基础医学院,北京100005)AbstractLipoproteindisordersresultfromabnormalsynthesis,processing,o... Lipoprotein disorders result from abnormal synthesis,processing,or catabolism of plasma lipoprotein particles.A number of studies indicate the presence of genetic factors that accelerate ageassociated cardiovascular changes seen in general population.Four types of lipoprotein abnormalities are observed:elevated LDL cholesterol;reduced HDL cholesterol,usually with increased triglycerides and verylowdensity lipoprotein(VLDL) cholesterol;elevated levels of chylomicron rennants and intermediatedensity lipoproteins(IDL);and elevated levels of lipoprotein(a)〔Lp(a)〕particles.Lipoprotein transport genes have been implicated in each of these abnormal lipoprotein phenotypes.
出处 《基础医学与临床》 CSCD 1997年第6期1-6,共6页 Basic and Clinical Medicine
关键词 脂蛋白代谢紊乱 心血管疾病 遗传学 lipoprotein disorders genetics
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  • 1Ma Y,Circulation,1993年,88卷,suppl期,179页

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