家族性混合型高脂血症的发病机理及转基因动物研究进展

Advances in Pathogenesis of Familial Combind Hyperlipidemia and Transgenic Animal Model

家族性混合型高脂血症的发病机理及转基因动物研究进展（中国医学科学院中国协和医科大学阜外心血管病医院心血管病研究所，北京１０００３７）裴卫东黄尚志＊惠汝太＊ＡｂｓｔｒａｃｔＦａｍｉｌｉａｌＣｏｍｂｉｎｅｄＨｙｐｅｒｌｉｐｉｄｅｍｉａ（ＦＣＨＬ）ｗａｓｆ...

Familial Combined Hyperlipidemia(FCHL)was first described as a new genetic disorder in 1973 by Goldstein and Rose.Among survivors premature myocardial infarction (below the age of 60 yr),FCHL was the most common familial lipid disorder(11～15%).FCHL may be present in 0.5～2% of the population.Apparently,FCHL is clustered in families and pedigree studies have suggested that it is inhertited as an autosomal dominant disorder.This article reviews the general character and pathogenesis of FCHL and new advances of transgenic mice in FCHL