星形细胞瘤的PCNA免疫组织化学研究

Immunohistochemical Study of PCNA in Cerebral Astrocytomas

对５３例星形细胞瘤进行增殖细胞核抗原（ＰＣＮＡ）的免疫组化观察。按照ＤａｕｍａｓＤｕｐｏｒｔ方法，本组病例Ⅱ级星形细胞瘤１４例，Ⅲ级１４例，Ⅳ级２５例；它们的ＰＣＮＡ阳性细胞标记指数分别为２．９９％，９．７３％和３８．０６％。结果表明：ＰＣＮＡ标记指数随着肿瘤组织病理分级的增高而增大，而且小细胞增殖区的标记指数明显高于多形性瘤细胞区。ＰＣＮＡ能反映肿瘤细胞的增殖速率。此项研究可用于判断星形细胞瘤的恶性程度，为临床判断病人的预后提供一个有价值的指标。

Immunohistochemical study of PCNA in 53 cases of astrocytomas was reported. According to the criterion of DaumasDuport's histological grading, the above mentioned astrocytomas included 14 cases of grade Ⅱ, 14 cases of grade Ⅲ and 25 cases of grade Ⅳ. The mean values of immunohistochemical labeling indices (LI) of PCNA are 2.99%, 9.73%and 38.06% respectively. The result showed that there existed a positive relation between the histological grading of astrocytomas and the immunohistochemical LI of PCNA, and LI of PCNA in the proliferating areas of small cell type were higher than that of proliferating areas of multiform cell type. PCNA can reflect the proliferating ratio of tumors. We can apply this work for judging the malignancy of astrocytomas and providing a valuable index for clinical prognosis of patients. 