老年人肥胖与脂类代谢紊乱、心脑血管疾病危险因素相关性的研究

Relationship among Senile Obesity,Lipid and Lipoprotein Metabolism and Cardiovascular Disease in Old Subjects

根据体重指数（ＢＭＩ），将６２３例老年人分为消瘦、正常、超重、肥胖４组（ＢＭＩ＜２０、２０～、２４～及２８～）。检测其身高、体重、血压、空腹血糖、胆固醇、甘油三酯及超声心动图。发现随ＢＭＩ增加，抽测人群平均年龄下降；超重与肥胖者的胆固醇及甘油三酯水平明显增加（Ｐ均＜０．０５）；体重、ＢＭＩ、收缩压及血糖均与胆固醇及甘油三酯呈明显正相关（Ｐ＜０．０５及０．００１），舒张压与胆固醇呈正相关（Ｐ＜０．０１）。多元逐步回归示除收缩压外，胆固醇、甘油三酯、血糖及舒张压均与ＢＭＩ呈正相关，均是影响ＢＭＩ的独立因素。结果提示肥胖与糖代谢及脂代谢紊乱密切相关。

The healthy status of 623 elderly subjects aged 60 years and above was examined including height, weight, blood pressure, fasting blood sugar(BS), total cholesterol(TC), triglyceride(TG), electrocardiogram and echocardiogram. The subjects were divided into four subgroups according to their body mass index(BMI): thin (BMI<20), normal(BMI 20～), overweight(BMI 24～)and obese (BMI 28～). It was found that with increasing in BMI, the average age of the subjects decreased. In obese and overweight groups TC and TG were statistically significantly increased (P all<0.05). There were positive correlations among TC, TG and weight, BMI, systolic blood pressure and BS(P<0.05 and 0.001,respectively); negative correlation between TC and diastolic blood pressure(P<0.01). Stepwise multivariate regression analysis disclosed that TC, TG, BS and DBP all alone and jointly positively correlated with BMI except SBP. It was suggested that obesity is one of the important risk factors for cardiovascular disease.