高血压病患者脂类代谢与纤溶系统的变化及意义

Clinical Significance of Serum Lipoprotein, Apolipoprotein and Lipid Levels and Marker of Thrombin Activation in Patients with Essential Hypertension

为探讨高血压病与动脉粥样硬化的相关关系，观察了２５例高血压病患者与２０例健康人脂类代谢与纤溶系统的变化。发现高血压组较对照组载脂蛋白Ａ、纤溶酶元及组织型纤溶酶元激活物明显下降（Ｐ＜０．００１及０．０５），氧化型低密度脂蛋白及纤溶酶元激活物抑制剂明显升高（Ｐ＜０．０５及０．００１），提示高血压病是致动脉粥样硬化的重要危险因素之一。

For investigating the relationship between essential hypertension and atherosclerosis, metabolism of lipids and marker of thrombin activation in 25 patients with essential hypertension and 20 normal subjects were observed. It was found that apoA and PGA were significant lower and PAI were significant higher in hypertension group than in control group (P<0.001 and 0.01), there was positive correlation between systolic hypertension and oxLDL (P<0.01). It is suggested that essential hypertension is one of the important dangerous factors in inducing atherosclerosis.