高锌摄入对正常小鼠脏器抗氧化功能及一氧化氮含量的影响

Effects of High Dietary Zinc on Normal Mice——Influence on Antioxidant and Nitric Oxide Content of Interal Organs

本研究结果表明，高锌可使小鼠心、脾、肾、胰腺、眼球及肝线粒体脂质过氧化产物ＭＤＡ含量明显升高，谷胱甘肽过氧化物酶活性明显下降，对脑、肝微粒体及肝胞浆无显著影响。对超氧化物歧化酶和过氧化氢酶活性的影响因脏器不同而不同。高锌可使小鼠心脏上述两种抗氧化酶的活性升高，对其它脏器酶活性或下降或无明显影响。提示高锌对诸多脏器抗氧化功能的危害。此外，高锌可使小鼠心、肾一氧化氮含量显著下降，而使脑、脾、胰、肝脏等脏器一氧化氮含量明显升高，提示一氧化氮可能参与了高锌所致某些生理功能障碍的发生、发展过程。

The effects of high dietary zinc on antioxidant and nitric oxide content of interal organs were studied.In the high dietary zinc group,1.GSH Px activity in heart,spleen,kidney,pancreas,eyeball and liver mitochondria decreased sharply;2.SOD activity in heart was raised significantly and in spleen and liver microsome decreased significantly;3.H 2O 2 ase activities in liver mitochondria and microsome were raised,and in spleen and kidney decreased significantly;4.MDA production in heart,spleen,kidney pancreas,eyeball and liver mitiochodria were raised significantly; 5.Nitric oxide content in brain,spleen,pancreas and liver increased significantly and decreased in heart,kidney.It demonstrated that the high dietary zinc may relate to some physiological function disorders.