摘要
本文研究了微晶纤维素,硬脂酸和甘露醇等辅料对黄原胶为载体的缓释片的释药性能的影响。结果表明,当缓释片中黄原胶浓度达16%以上时,选用适量的硬脂酸或甘露醇作辅料,可以获得缓慢释药的片剂;当黄原胶浓度达20%以上时,才可考虑选用微晶纤维素。
The objective of this study was to evaluate the effect of excipients, including microcrystline cellulose(Avicel), stearic acid and mannitol on sustainedrelease behavior of tablets formed by Xanthan gum, and to develop the application of xanthan gum to sustainedrelease tablets. The results indicated that the tablets for sustainedrelease drug were obtained when the concentration of Xanthan gum in the tablets was selected as excipient; only when the concentration of Xanthan gum in tablets was selected as excipient; only when the concentration of xanthan gum in tablets was above 16% and mannitol or stearic acid was above 20%, micocrystaline cellulose could be considerated to be used to prepare the sustainedrelease tablets.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1997年第6期338-341,共4页
Journal of China Pharmaceutical University
关键词
黄原胶
扑热息痛
缓释片
微晶纤维素
硬脂酸
Xanthan gum
Acetaminophen
Sustainedrelease tablet
Microcrystaline cellulose
Stearic acid
Mannitol