血清β-HCG变化在评价早孕药物流产预后中的价值

A Retrospective Study on the Significance of Changes of Serum β-HCG Levels After Drug-Induced Abortion for Outcome Prediction

目的:评价药物流产前后血清β-HCG变化程度与药物流产后阴道出血时间的关系。方法:检测药物流产前及药物流产后15d药流妇女的血清β-HCG水平,回顾性分析其变化情况与阴道出血时间的关系。结果:药流后第15d血清β-HCG值中位数正常组、出血延长组与清宫组之间有极显著性差异(P<0.01);三组间血清β-HCG改变率的差异更显著(P<0.001)。结论:血清β-HCG改变率不受个体β-HCG初始浓度影响,可预测药流后阴道出血时间是否延长,从而早期判断预后,为尽早给予临床干预提供依据。

Objective To investigate the relationship between the changes of serum β - HCG levels and duration of vaginal bleeding after drug - induced abortion. Methods The initial serum β- HCG levels and the level on d15 after drug - induced abortion were collected from the history record of 300 women undergoing drug - induced abortion. The condition of vaginal bleeding was noted. Results Among the 300 patients, 120 had their vagiral bleeding stopped before d15 （ Group A）. Group B consisted of 100 patients with prolonged vaginal bleeding over d15 and Group C consisted of 80 women with prolonged vaginal bleeding requiring a final curettage. The median value of serum 13 - HCG level of the three groups on d15 was 46, 95 and 582 respectively with significant differencea among them （P 〈0.01 ）. The ratio of d15 value initial value in the three groups was 0.0131, 0. 0306 and 0. 1492 respectively with even more significant differences （P 〈 0. 001 ）. Conclusion The ratio of serum β - HCG levels over initial value changes rate on d15 after drug - induced abortion might reliably predict the outcome of the treatment, i. e. totally successful or requiring a final