口腔颌面部血管瘤和血管畸形的肥大细胞数量与雌激素受体水平分析

ANALYSIS ON MAST CELL COUNT AND ESTROGEN RECEPTOR LEVEL IN ORAL MAXILLOFACIAL HEMANGIOMA AND VASCULAR MALFORMATION

分析口腔颌面部血管瘤和血管畸形的肥大细胞数量与雌激素受体（ER）水平及其在血管瘤增殖中的作用。方法：采用甲苯胺蓝染色法及免疫组化法对34例血管成和14例血管畸形病理标本进行分析。结果：血管瘤增殖期与退化期肥大细胞数量之间的差别有高度统计学意义（P＜0．01）；ER（－）与ER（＋＋）时的肥大细胞数量之间的差别有高度统计学意义（P＜0.01）；血管瘤增殖期与退化期ER阳性率的差别无统计学意义（P＞0．20）。结论：肥大细胞计数有助于血管瘤与血管畸形的鉴别诊断；ER（＋＋）时有较多的肥大细胞参与血管瘤的生长。血管瘤增殖期比退化期的ER可能更具有活性。

Objective: To study the mast cell count, estrogen recoptor level and their role in the proiferation of hemangioma. Methods: The touidine blue stain and immunohistochemical technique were carried out.Results:The mast cell count in proliferative stage was higher than that in involuting stage (P< 0. 01). The mast cell count in ER " - " patients was lower than that in ER " + + " ones(P< 0. 01). The positive rate of ER had no significant different between proliferative and involuting stage hemangiomas (P> 0. 20).Conclusion: Mast cell count can help the differential diagnosis of hemangioma and vascular malformation.There are more mast cells taking part in the growth of hemangioma in ER " + + " patients. The activity of ER in proliferation stage may be higher than that in involuting stage.