阴沟肠杆菌的耐药性与抗菌药物使用量的相关性分析

Relationship Between Resistance of Enterobacter cloacae and Consumption of Antibiotics

目的调查2001-2006年阴沟肠杆菌的耐药性与抗菌药物年使用量,探讨用药量和耐药性之间的相关性。方法纸片扩散法进行药敏试验并对2001-2006年抗菌药物的年用药频度(DDDs)与阴沟肠杆菌的耐药率进行相关性分析。结果6年来阴沟肠杆菌对5种抗菌药物的耐药率呈下降趋势,其中对阿米卡星下降幅度最大,2006年与2005年相比耐药率下降了28.0%;5种抗菌药物用药量呈下降趋势,头孢他啶2006年用药量只有2004年用药量的1/12,环丙沙星2006年用药量只有2001年的1/8;耐药率和用药频度相关性分析显示,阴沟肠杆菌对阿米卡星的耐药率与阿米卡星的用药频度呈显著正相关(r=0.8826,P<0.05),也与环丙沙星用药频度呈显著正相关(r=0.9429,P<0.05)。结论2001-2006年阴沟肠杆菌对5种抗菌药物的耐药率呈下降趋势,阿米卡星的耐药率的下降不仅与其年用量下降呈显著正相关,并且与环丙沙星的年用量下降也呈显著正相关。

OBJECTIVE To investigate the quantity of antibiotics prescribed yearly from 2001 to 2006 and the resistance of Enterobacter cloacae, and analyze the correlation between them. METHODS Its susceptibility to antimicrobial agents was performed by disk diffusion method and analyzed by WHONET 5. 3. The correlation between DDDs and the resistance was analyzed using statistics. RESULTS The percentage of resistance of E. cloacae to the five drugs was decreased during recent six years. The most of decreased tendency was amikacin, its resistance in 2006 decreased 28% than that in 2001. The consumption of five drugs all decreased. The consumption of ceftazidime in 2006 was 1/12 compared in the 2004. The consumption of ciprofloxacin in 2006 was 1/8 compared in 2001. The analysis revealed a significant positive correlation between the resistance and DDDs of amikacin（r=0. 8826, P〈0.05）, the DDDs of ciprofloxacin was also related to the resistance of E. cloacae to amikacin respectively. CONCLUSIONS From 2001 to 2006, the percentage of resistance of E. cloacae to five drugs is tended to decrease. The correlation between the use of amikacin and its resistance in E. cloacae strains, also reveals an association between ciprofloxacin consumption and resistance to amikacin.