膀胱内灌注血卟啉衍生物加抗坏血酸全膀胱激光照射预防膀胱癌复发

Whole bladder wall laser irradiation to prevent bladder cancer recurrence with intravesical HpD and ascorbic acid

目的探讨预防膀胱癌术后复发的新疗法，评价经膀胱内灌注血卟啉衍生物加抗坏血酸行激光全膀胱照射的光动力疗法预防复发的疗效。方法采用经膀胱内灌注血卟啉衍生物癌光啉（ＰｓＤ－００７）加抗坏血酸行全膀胱激光照射方法，治疗３０例膀胱癌术后患者。结果３０例患者随诊３０个月，其肿瘤复发率为２３．３％（７／３０）。无一例发生膀胱挛缩以及皮肤光毒副反应。结论用膀胱内灌注血卟啉衍生物加抗坏血酸全膀胱照射能有效地预防膀胱癌的复发。在治疗过程中，受治患者无需避光护理，为治疗提供了方便。

Objective To evaluate the effect of whole bladder wall laser irradiation with intravesical HpD and ascorbic acid on bladder cancer recurrence. Methods Photodynamic therapy(PDT) was performed by intravesical instillation of hematoporphyrin derivative (HpD) PsD 007 containing ascorbic acid followed by whole bladder wall laser irradiation in 30 post operative cases of bladder cancer. Results The tumour recurrence rate was 23.3% (7/30) on follow up for 30 months after PDT. No photo sensitizing effects was found on the skin of patients, nor was retraction of bladder observed in any case of this series. Conclusion This method is effective in the prevention of bladder cancer recurrence. Protection from light is not necessary during treatment.