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新一代广谱氟喹诺酮类抗菌药物吉米沙星 被引量：17

A novel broad-spectrum fluoroquinolone gemifloxacin
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摘要 吉米沙星是韩国LG Life Science公司研制的第四代氟喹诺酮类抗菌新药,它同时作用于细菌DNA旋转酶和DNA拓扑异构酶IV,提高了抗菌活性,降低耐药率。吉米沙星除了保持对革兰阴性菌的强大抗菌活性外,对包括多重耐药性肺炎链球菌在内的革兰阳性菌也具有良好的活性。吉米沙星具有良好的药动学性质,组织渗透性强,能强力杀灭感染部位致病菌。它的药物间相互作用少,有较好的安全性和耐受性,是临床上治疗慢性支气管炎急性发作、社区获得性肺炎和急性鼻窦炎的良好药物。 Gemifloxacin is a novel, broad-spectrum fluoroquinolone. This review summarized the mechanism of action, antibacterial activity, pharmacokinetic, pharmacokinetic/pharmacodynamic, adverse effect and therapeutic effect of gemifloxacin.
作者 李然 王睿
机构地区 中国人民解放军总医院
出处 《中国抗生素杂志》 CAS CSCD 北大核心 2008年第8期453-460,共8页 Chinese Journal of Antibiotics
关键词 吉米沙星 氟喹诺酮 抗菌作用 药动学 临床疗效 Gemifloxacin Fluoroquinolone Antibacterial activity Pharmacokinetic Therapeutic effect
分类号 R978.1 [医药卫生—药品]
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参考文献32

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二级参考文献62

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中国抗生素杂志
2008年 第8期

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