皮内与皮下注射磷酸组胺对皮肤毛细血管通透性实验结果的影响

The Effect of Intradermal and Subcutaneous Histamine Phosphate Injecting on Capillary Permeability

目的:观察皮内注射与皮下注射磷酸组胺对皮肤毛细血管通透性实验结果的影响。方法:建立组胺所致毛细血管通透性增加模型,尾静脉注射伊文思蓝,测定伊文思蓝的渗出。结果:皮内注射与皮下注射磷酸组胺均可造成实验用模型。结论:在小鼠皮肤毛细血管通透性实验中可采用皮下注射组胺的方法。

Objective： To study the effect of intradermal and subcutaneous histamine phosphate injecting on capillary permeability. Methods： Mouse model of capillary permeability increased was established by injecting histamine. The exudation of Evans blue was determined by injecting Evans blue in the vena caudalis. Results： Mouse model of capillary permeability increased was established by intradermal and subcutaneous histamine phosphate injecting. Conclusions ： The method of histamine phosphate subcutaneous injecting was convenient. It can be applied in the capillary permeability experiment.