紫色球海胆EXT1基因的生物信息学分析

Bioinformatics Analysis of EXT1 Gene from Strongylocentrotus purpuratus

海胆基因组测序计划的顺利完成填补了基因组测序的一个空白,在生命科学领域中具有重要意义。利用生物信息学方法寻找人类遗传多发性外生性骨疣EXT1基因在紫色球海胆中的同源基因,对该基因的序列、外显子信息、编码蛋白及其理化性质进行分析,并预测其编码蛋白的结构与功能,构建其同源基因的系统进化树,旨在为进一步研究人体EXT1基因提供一定的依据。

The accomplishment of sea urchin genome sequencing project filled a gap in genome sequencing,which had the vital significance in the life sciences fields.Bioinformatics was used to seek the homologous gene of EXT1 in Strongylocentrotus purpuratus which was just discovered and had the correlation to human hereditary multiple exostoses.The sequence,exons,coding protein,physical and chemical characters of EXT1 gene were analyzed.The structure and function of its coding protein were predicted,and the phylogenetic tree for the homologous gene was constructed,which provided certain basis for the future research of human EXT1 gene.