凸面脑膜瘤增殖细胞核抗原表达与其硬脑膜侵袭性的临床研究

Clinical study on the relationship of the expressions of proliferating cell nuclear antigen and endocraninm invasion in the convex meningiomas

目的探讨凸面脑膜瘤增殖细胞核抗原（PCNA）表达与其硬脑膜侵袭性的关系。方法选取经手术和病理证实的凸面脑膜瘤患者51例，术中均切取肿瘤基底周围至少15mm的硬脑膜，随机切取0～1、2、5、6～10、〉10mm 4段，瘤体标本均行病理切片HE染色光镜检查，亦行PC—NA免疫组化染色观察，并进行统计学分析。结果硬脑膜有肿瘤细胞侵袭者PCNA标记指数（u）为10．32±6．74，硬脑膜无肿瘤细胞侵袭者PCNALI为2．16±4．93，两者比较差异有统计学意义（t=0．876，P〈0．05）。非典型性脑膜瘤瘤周硬脑膜受侵袭率明显高于其他病理分型脑膜瘤。结论PCNA免疫组化表达强度与瘤周硬脑膜受侵袭情况存在相关性，这可能与肿瘤病理分级有关。

Objective To evaluate the relationship of the expressions of proliferating cell nuclear antigen （PCNA） and endocranium invasion in the convex meningiomas. Methods Convex meningioma Simpson I level excises 51 patients were selected. The dural mater 15 mm around the tumors was resected, stochastically divided into four sections （0-1 mm, 2-5 mm, 6-10mm, 〉 10 mm）for pathological inspection. Analysed statistically the study results based on microscopic observation of the HE staining slides and immunohistochemistry of proliferating cell nuclear antigen（PCNA）. Results PCNA LI of the group with the endocranium invasion was 10.32 ＋ 6.74,the other was 2.16 ＋ 4.93. The atypical meningioma had a high endocranium invasion degree. Condnsion Pathologic grading of meningioma and the expressions of PCNA by immunohistochemical staining method are the factors affecting endocranium invasion of the convex meningiomas.