B淋巴细胞刺激因子与系统性红斑狼疮

B Lymphocyte Stimulator and Systemic Lupus Erythematosus

B淋巴细胞刺激因子(Blys)是肿瘤坏死因子配体超家族成员,可刺激B淋巴细胞增殖、分化及分泌抗体,对机体的免疫应答、尤其是体液免疫应答起着关键性作用。Blys缺陷或过量表达均可引起机体免疫失衡,诱发多种自身免疫性疾病。Blys mRNA可能是SLE疾病活动性的一个有用的生物学标志,Blys拮抗剂为SLE的治疗带来新的研究方向。

B lymphocyte stimulator （Blys） is a member of the tumour necrosis factor （TNF） superfamily that regulates B lymphocyte proliferation, differentiation and antibody secretion. Blys plays a key role in immune responses, especially in humoral immune responses. Deficiency or overexpression of Blys results in immune inbalance and induces several autoimmune diseases. Blys mRNA may serve as an useful biomarker of disease activity in systemic lupus erythematosus （SLE）. For autoimmune diseases in which B cells have a pathogenic role, such as SLE, Blys antagonism might be an useful therapeutic strategy.