瘦素与自身免疫病

Leptin and Autoimmune Disease

瘦素是一种主要由脂肪组织分泌的蛋白质类激素,除在能量消耗方面发挥效应外,在免疫应答和自身免疫病发病机制中也发挥着重要作用,本文就瘦素的生物学特性和功能、免疫调节作用及与自身免疫病的关系做一综述。

Leptin is a kind of proteohormone secreted by adipose tissues. Although leptin is known for its regulation of metabolism, it has many emerging roles in immune function and the pathogenesis of autoimmune disease （AD）. This article reviews the biological character, function and immunoregulation effect of leptin and the relationship between leptin and AD.