血必净注射液对无创通气治疗慢性阻塞性肺疾病的影响

Effects of Xuebijing Injection on the Clinical Efficacy of Noninvasive Ventilation in Patients with Chronic Obstructive Pulmonary Disease

目的观察血必净注射液对接受无创正压通气治疗慢性阻塞性肺疾病(COPD)患者的影响。方法对照组20例在给予常规治疗的同时无创通气,治疗组20例在常规治疗无创通气的基础上加用血必净注射液100ml静滴,每日2次,共10d;对所有患者进行血氧饱和度等监测,分别于治疗前及治疗后8h、24h、3d、7d行动脉血气分析,并记录神志、呼吸、心率、呼吸困难等在各个治疗时期的变化。结果治疗组患者均明显好转出院,对照组治疗后3例无改善而改用有创通气治疗,其余17例患者均好转出院;住院时间及机械通气时间治疗组均短于对照组;3d、7d时呼吸困难计分、动脉血气分析结果治疗组均明显优于对照组;面部压伤、感染等不良反应治疗组明显减少。结论血必净注射液对无创通气治疗COPD能明显缩短患者住院和机械通气时间,不良反应发生率明显下降。

Objective： To study the effect of Xuebijing Injection on the clinical efficacy of noninvasive positive pressure ventilation （NPPV） in treating partients with chronic obstructive pulmonary disease （ COPD ） . Methods： Patients in the control group（ n = 20） were treated with conventional therapy plus NPPV, and those in the treatment group（ n = 20） received the same treatment with Xuebijing Injection 100ml twice a day additionally. The treatment lasted for 10 days. Arterial oxygen saturation（SaO2） was conitinuously monitored in all patients, arterial blood gas values was determined before treatment and at the 6th hour, the 23th hour, the 3rd day and the 7th day after treatment, and consciousness, breath, heart rate and severity of dyspnea were observed during the treating period. Results： All patients in the treatment group were markedly improved and discharged from hospital, while in the control group 17 were improved and discharged from hospital, but the other 3 failed to be remitted and received the conventional invasive mechanical ventilation. The duration of hospitalization and ventilation were shorter in the treatment group than the control group. The dyspnea score and the arterial bolld gas values determined on the 3rd and 7th day were significantly improved in the treatment group than those in the control group. The incidence of endotracheal intubation caused adverse reacition, such as facial - skin crush wound , abdominal distention and contaminated infection in the treatment group was obviously lessened as compared with the control group. Conclusion： Xuebijing Injection could shorten the duration of hospitalization and mechanical ventilation, reduce trachea cannulation, and decrease the incidence of complications and adverse reactions in the patients with sever RF due to COPD treated with NPPV.