柴胡皂苷A对抑郁模型大鼠脑中单胺类神经递质及其代谢产物含量的影响

Influence of Saikosaponina A on Monoamine Neurotransmitters and the Corresponding Metabolin Compositions in Depressed Rats' Brain

在酸性条件下,利用高效液相色谱法研究了柴胡皂苷A对抑郁模型大鼠脑中单胺类神经递质及其代谢物含量的影响.实验结果表明,柴胡皂苷A可使抑郁型大鼠脑中的高香草酸、去甲肾上腺素、多巴胺及5-羟色胺的含量升高,这一结果有利于对柴胡皂苷治疗抑郁症的物质基础及相关机理进行更深入了解.

The high performance liquid chromatography was applied to investigate the influence of the chemical composition, saikosaponina A, on monoamine neurotransmitter in the depressed rats＇ brain. It is shown from the analytical results that in the depressed rats＇ brain, the contents of homovanillic acid, noradrenaline, dihydroxyphenyl ethylamine and 5-HT increase in the presence of the saikosaponin A. These results can help to clarify the mechanism of saikosaponin A in curing the depression.