血清胱抑素C对诊断早期肾功能损害的临床价值被引量：22

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摘要目的:探讨血清胱抑素C(cystatin C,Cys-C)的检测对诊断肾脏病患者早期肾功能损害的临床价值。方法:采用胶乳增强免疫比浊法、UV-GLDH法和Jaffe法分别测定40例健康对照者和39例肾病患者肾功能不全各期的血清Cys-C、尿素(Urea)和血肌酐(Scr)浓度,并对各组血清Cys-C、Urea和Scr进行分析比较。结果:肾病患者在肾功能正常期和肾功能储备下降期仅Cys-C与健康对照者有显著性(P<0.01),而在肾功能不全期、肾功能衰竭期和尿毒症期Cys-C、Scr和Urea均与健康对照者差异有显著性(P<0.01或P<0.05)。再者,Cys-C与内生肌酐清除率(Ccr)呈显著负相关(P<0.001),且优于Scr、Urea与Ccr的相关性。在肾功能损害早期,血清Cys-C的阳性检出率和准确度比Scr、Urea高。结论:与Ccr、Urea和Scr相比,血清Cys-C是一种更为敏感、准确地反映肾小球滤过功能的指标,对早期诊断肾脏病患者肾小球滤过功能的损害具有重要价值。

作者李朝霞帅小明罗敏琪梁敏坚

机构地区中山大学附属第三医院检验科贵阳医学院

出处《实用医学杂志》 CAS 2008年第16期2803-2804,共2页 The Journal of Practical Medicine

关键词肾疾病胱抑素C 肾小球滤过率肾功能损害

分类号 R692 [医药卫生—泌尿科学]

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参考文献6

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二级参考文献16

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