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核转录因子κB与子宫内膜异位症发病机制 被引量:3

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摘要 已证实子宫内膜异位症(EMs)的发病机制与免疫、细胞凋亡、激素水平异常等因素相关。核转录因子κB(NF-κB)在正常情况下与其负调控蛋白结合处于失活状态,当细胞接受外来刺激后这种结合被破坏,活化的NF-κB与其靶基因启动子结合后促进基因表达。NF-κB的靶基因产物中有许多与炎症反应、细胞凋亡、激素合成相关分子,并且部分靶基因产物可以激活NF-κB,从而形成一条正反馈途径,使NF-κB及其靶基因产物的生物学效应得到放大。NF-κB可能通过其靶基因直接或间接地参与EMs发病。
出处 《国际妇产科学杂志》 CAS 2008年第4期265-268,共4页 Journal of International Obstetrics and Gynecology
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